Why Take Aspirin?

Aspirin therapy is well-accepted as an agent for the prevention of cardiovascular events and has been shown to reduce the incidence of vascular death by ~15 % and nonfatal vascular events by ~30 %.(1)

Why is 100 mg of aspirin more effective than ~80 mg?

The ideal daily dose to ensure sufficient aspirin is delivered to reduce platelet aggregation is 75-150 mg.(2)

Does enteric coating make a difference?

Enteric coating is said to reduce GI bleeding by allowing the aspirin to pass through the stomach to the small intestine before dissolving, but studies show that enteric coated aspirin does not decrease the risk of gastrointestinal bleeding compared with uncoated aspirin.(4,5)

There is also evidence that not all the aspirin in a coated tablet reaches the bloodstream, thereby reducing its effects.(1)

Aspirin tablets are not expected to produce GI bleeding any greater than aspirin of lower doses or those that have enteric coating.